Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8NFH3
UPID:
NUP43_HUMAN
Alternative names:
Nup107-160 subcomplex subunit Nup43; p42
Alternative UPACC:
Q8NFH3; B4E2F0; Q9H8S0
Background:
Nucleoporin Nup43, known as Nup107-160 subcomplex subunit Nup43 or p42, plays a pivotal role in the nuclear pore complex (NPC) assembly and function. This protein is essential for the Nup107-160 subcomplex's involvement in kinetochore microtubule attachment, mitotic progression, and chromosome segregation, highlighting its critical function in cellular division and genetic stability.
Therapeutic significance:
Understanding the role of Nucleoporin Nup43 could open doors to potential therapeutic strategies. Its fundamental involvement in mitotic progression and chromosome segregation positions it as a key target for interventions in diseases characterized by abnormal cell division and genetic instability.