Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8NG68
UPID:
TTL_HUMAN
Alternative names:
-
Alternative UPACC:
Q8NG68; Q585T3; Q7Z302; Q8N426
Background:
Tubulin--tyrosine ligase plays a crucial role in cellular structure and function by catalyzing the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. This enzyme is pivotal in maintaining the dynamic balance between detyrosinated and tyrosinated alpha-tubulin, essential for microtubule assembly and function.
Therapeutic significance:
Understanding the role of Tubulin--tyrosine ligase could open doors to potential therapeutic strategies. Its critical function in microtubule dynamics suggests its involvement in cellular processes that are often dysregulated in diseases. Targeting this enzyme could lead to novel treatments for conditions where microtubule function is compromised.