Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8NHS3
UPID:
MFSD8_HUMAN
Alternative names:
Ceroid-lipofuscinosis neuronal protein 7
Alternative UPACC:
Q8NHS3; B2RDM1; B7Z205; Q8N2P3
Background:
Major facilitator superfamily domain-containing protein 8, also known as Ceroid-lipofuscinosis neuronal protein 7, plays a crucial role in the transport of small solutes across membranes, leveraging chemiosmotic ion gradients. This protein's involvement in cellular transport mechanisms highlights its fundamental role in maintaining cellular homeostasis and function.
Therapeutic significance:
The protein is directly associated with diseases such as Ceroid lipofuscinosis, neuronal, 7, and Macular dystrophy with central cone involvement, both of which have profound impacts on neurological and visual health. Understanding the role of Major facilitator superfamily domain-containing protein 8 could open doors to potential therapeutic strategies for these debilitating conditions.