Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8TAM1
UPID:
BBS10_HUMAN
Alternative names:
-
Alternative UPACC:
Q8TAM1; Q96CW2; Q9H5D2
Background:
The Bardet-Biedl syndrome 10 protein, encoded by the gene with accession number Q8TAM1, is implicated in a range of critical cellular processes. It functions as a probable molecular chaperone, facilitating protein folding upon ATP hydrolysis. This protein is pivotal in the assembly of the BBSome complex, essential for ciliogenesis and vesicle transport to cilia, and plays a significant role in adipogenic differentiation.
Therapeutic significance:
Given its involvement in Bardet-Biedl syndrome 10, a condition marked by severe pigmentary retinopathy, obesity, polydactyly, and other systemic manifestations, the Bardet-Biedl syndrome 10 protein represents a promising target for therapeutic intervention. Understanding the role of this protein could open doors to potential therapeutic strategies, particularly for tackling the multifaceted symptoms of Bardet-Biedl syndrome.