Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8TAM2
UPID:
TTC8_HUMAN
Alternative names:
Bardet-Biedl syndrome 8 protein
Alternative UPACC:
Q8TAM2; A6NFG2; B3KWA5; Q67B97; Q86SY0; Q86TV9; Q86U26; Q8NDH9; Q96DG8
Background:
The Tetratricopeptide repeat protein 8, also known as Bardet-Biedl syndrome 8 protein, plays a crucial role in ciliogenesis and the sonic hedgehog (SHH) pathway regulation. It is part of the BBSome complex, essential for sorting specific membrane proteins to the primary cilia and proper assembly and localization of the BBSome complex.
Therapeutic significance:
Linked to Retinitis pigmentosa 51 and Bardet-Biedl syndrome 8, understanding the role of Tetratricopeptide repeat protein 8 could open doors to potential therapeutic strategies for these genetic disorders, focusing on restoring vision and managing obesity, polydactyly, and intellectual disability.