Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8TAT6
UPID:
NPL4_HUMAN
Alternative names:
-
Alternative UPACC:
Q8TAT6; Q8N3J1; Q9H8V2; Q9H964; Q9NWR5; Q9P229
Background:
Nuclear protein localization protein 4 homolog (NPLOC4) plays a pivotal role in cellular processes, including the export of misfolded proteins from the ER to the cytoplasm for degradation, regulation of spindle disassembly at the end of mitosis, and formation of a closed nuclear envelope. It forms a ternary complex with UFD1 and VCP, essential for these processes. Additionally, NPLOC4 acts as a negative regulator of type I interferon production, highlighting its multifaceted role in cellular homeostasis and immune response.
Therapeutic significance:
Understanding the role of Nuclear protein localization protein 4 homolog could open doors to potential therapeutic strategies. Its involvement in protein degradation, cell cycle regulation, and immune response modulation presents a unique opportunity for targeting diseases where these processes are dysregulated.