Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8TAX9
UPID:
GSDMB_HUMAN
Alternative names:
Gasdermin-like protein
Alternative UPACC:
Q8TAX9; B4DKK7; Q7Z377; Q8WY76; Q9NX71; Q9P163
Background:
Gasdermin-B, identified by its accession number Q8TAX9, is a precursor of a pore-forming protein pivotal in granzyme-mediated cell death. It plays a crucial role in pyroptosis, a form of programmed cell death, by forming pores in membranes upon cleavage by granzyme A. This protein is also involved in epithelial cell repair and maintenance, independent of its cell death functions, by regulating phosphorylation processes crucial for cell repair.
Therapeutic significance:
Understanding the role of Gasdermin-B could open doors to potential therapeutic strategies. Its involvement in both cell death and repair mechanisms positions it as a key target for developing treatments aimed at modulating immune responses and facilitating tissue repair.