Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8TBZ3
UPID:
WDR20_HUMAN
Alternative names:
Protein DMR
Alternative UPACC:
Q8TBZ3; B4DN18; E7EUY8; F8W9S4; G3V2F8; G3V5R0; H0YJJ1; Q86TU2; Q8NCN7; Q8WXX2; Q9UF86
Background:
WD repeat-containing protein 20, also known as Protein DMR, plays a crucial role as a regulator of deubiquitinating complexes. It specifically activates the deubiquitinating activity of complexes containing USP12, as evidenced by research findings. This protein anchors at the base of the ubiquitin-contacting loop of USP12, remotely modulating the catalytic center of the enzyme, which highlights its significance in protein regulation.
Therapeutic significance:
Understanding the role of WD repeat-containing protein 20 could open doors to potential therapeutic strategies. Its pivotal function in regulating deubiquitinating complexes suggests its involvement in cellular processes that are critical for maintaining cellular homeostasis and potentially combating diseases.