Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8TC36
UPID:
SUN5_HUMAN
Alternative names:
Sad1 and UNC84 domain-containing protein 5; Sperm-associated antigen 4-like protein; Testis and spermatogenesis-related gene 4 protein
Alternative UPACC:
Q8TC36; A6NJ82; Q5T9R0
Background:
SUN domain-containing protein 5, also known as Sad1 and UNC84 domain-containing protein 5, Sperm-associated antigen 4-like protein, and Testis and spermatogenesis-related gene 4 protein, is pivotal in male fertility. It ensures the structural integrity of sperm by anchoring the sperm head to the tail, facilitating successful fertilization.
Therapeutic significance:
Linked to Spermatogenic failure 16, a condition marked by defective sperm morphology leading to infertility, SUN domain-containing protein 5's role in spermatogenesis highlights its potential as a target for therapeutic intervention to restore fertility in affected individuals.