Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8TC59
UPID:
PIWL2_HUMAN
Alternative names:
Cancer/testis antigen 80
Alternative UPACC:
Q8TC59; A8K4S3; A8K8S5; B0AZN9; B0AZP2; B4DR22; E7ECA4; Q96SW6; Q9NW28
Background:
Piwi-like protein 2, also known as Cancer/testis antigen 80, plays a pivotal role in spermatogenesis by repressing transposable elements, crucial for germline integrity. It is instrumental in meiotic differentiation, germ cell differentiation, and spermatogonial stem cell self-renewal through the piRNA metabolic process. This process involves piRNA and Piwi protein complexes that govern transposon methylation and repression. Piwi-like protein 2 is key in piRNA biosynthesis, particularly in the ping-pong amplification cycle, acting as a 'slicer-competent' endoribonuclease.
Therapeutic significance:
Understanding the role of Piwi-like protein 2 could open doors to potential therapeutic strategies.