Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8TCD5
UPID:
NT5C_HUMAN
Alternative names:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1
Alternative UPACC:
Q8TCD5; Q96HS6; Q9NP82
Background:
The 5'(3')-deoxyribonucleotidase, cytosolic type, known alternatively as Cytosolic 5',3'-pyrimidine nucleotidase or Deoxy-5'-nucleotidase 1, plays a crucial role in nucleotide metabolism. It specifically dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, showing a preference for dUMP and dTMP. Its activity towards dGMP is intermediate, while it exhibits low activity towards dCMP and dAMP.
Therapeutic significance:
Understanding the role of 5'(3')-deoxyribonucleotidase, cytosolic type could open doors to potential therapeutic strategies.