Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8TDH9
UPID:
BL1S5_HUMAN
Alternative names:
Protein Muted homolog
Alternative UPACC:
Q8TDH9; B4DVM2; Q0VDJ6; Q0VDJ7; Q5THS1; Q68D56; Q8N5F9; Q9NU16
Background:
Biogenesis of lysosome-related organelles complex 1 subunit 5, also known as Protein Muted homolog, plays a pivotal role in the formation of lysosome-related organelles. It is a component of the BLOC-1 complex, essential for the biogenesis of platelet dense granules and melanosomes. This protein is involved in vesicle trafficking, targeting membrane protein cargos for delivery into neurites and nerve terminals, and is associated with SNARE proteins in neurite extension.
Therapeutic significance:
Hermansky-Pudlak syndrome 11, a disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects, is caused by variants affecting this gene. Understanding the role of Biogenesis of lysosome-related organelles complex 1 subunit 5 could open doors to potential therapeutic strategies for this syndrome.