Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8TEA7
UPID:
TBCK_HUMAN
Alternative names:
-
Alternative UPACC:
Q8TEA7; B9A6J1; Q4W5B3; Q4W5E1; Q6NUP4; Q8N7M8; Q8WW57; Q96GV6; Q9P080
Background:
The TBC domain-containing protein kinase-like protein plays a pivotal role in cellular processes, including mTOR signaling modulation, cell proliferation, growth, and actin-cytoskeleton organization. Its involvement in these critical pathways underscores its importance in maintaining cellular homeostasis and function.
Therapeutic significance:
Linked to Hypotonia, infantile, with psychomotor retardation and characteristic facies 3, this protein's dysfunction highlights its potential as a therapeutic target. Understanding the role of TBC domain-containing protein kinase-like protein could open doors to potential therapeutic strategies.