Focused On-demand Library for Rhomboid-related protein 4

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

Our top-notch dedicated system is used to design specialised libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.

Our library stands out due to several important features:

  • The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
  • Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
  • Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
  • Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.







Alternative names:

Rhomboid domain-containing protein 1; Rhomboid-like protein 4

Alternative UPACC:

Q8TEB9; Q495B9; Q53S43; Q5EBM8; Q6P5V8; Q8IV60; Q9H057


Rhomboid-related protein 4, also known as Rhomboid domain-containing protein 1 or Rhomboid-like protein 4, plays a pivotal role in cellular processes. It functions as an intramembrane-cleaving serine protease, targeting single or multi-pass membrane proteins. This protein is essential in regulated intramembrane proteolysis, facilitating the release of functional polypeptides. It is a key component of the endoplasmic reticulum-associated degradation pathway for misfolded membrane proteins, aiding in their transfer to the cytosol for destruction. Additionally, it is involved in apoptosis regulation and spermatogenesis, highlighting its multifaceted biological significance.

Therapeutic significance:

Understanding the role of Rhomboid-related protein 4 could open doors to potential therapeutic strategies.

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