Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8TED0
UPID:
UTP15_HUMAN
Alternative names:
-
Alternative UPACC:
Q8TED0; B4DU75; B4DXK8; Q6IA60; Q96E08; Q9H9F8
Background:
U3 small nucleolar RNA-associated protein 15 homolog plays a pivotal role in ribosome biogenesis, specifically in the nucleolar processing of pre-18S ribosomal RNA. It is essential for the transcription of pre-ribosomal RNA by RNA polymerase I and is a key component of the small subunit (SSU) processome. This protein facilitates RNA folding, modifications, rearrangements, and cleavage, and is involved in the targeted degradation of pre-ribosomal RNA.
Therapeutic significance:
Understanding the role of U3 small nucleolar RNA-associated protein 15 homolog could open doors to potential therapeutic strategies.