Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8TEQ6
UPID:
GEMI5_HUMAN
Alternative names:
-
Alternative UPACC:
Q8TEQ6; Q14CV0; Q8WWV4; Q969W4; Q9H9K3; Q9UFI5
Background:
Gem-associated protein 5 plays a pivotal role in the assembly of small nuclear ribonucleoproteins (snRNPs), essential for pre-mRNA splicing. This process is crucial for the accurate expression of genetic information. The protein facilitates the formation of the spliceosome by catalyzing the assembly of snRNPs, which are integral to the splicing of cellular pre-mRNAs. Its ability to bind to the 7-methylguanosine cap of RNA molecules and regulate the translation of SMN1 mRNA highlights its multifaceted role in RNA metabolism.
Therapeutic significance:
The protein is linked to Neurodevelopmental disorder with cerebellar atrophy and motor dysfunction, a condition characterized by developmental delays, motor abnormalities, and cognitive impairment. Understanding the role of Gem-associated protein 5 could open doors to potential therapeutic strategies for this disorder, emphasizing the importance of targeted research in unraveling its biological functions and therapeutic potential.