Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8TEX9
UPID:
IPO4_HUMAN
Alternative names:
Importin-4b; Ran-binding protein 4
Alternative UPACC:
Q8TEX9; B2RN95; Q2NL96; Q86TZ9; Q8NCG8; Q96SJ3; Q9BTI4; Q9H5L0
Background:
Importin-4, also known as Importin-4b and Ran-binding protein 4, is a pivotal nuclear transport receptor. It facilitates the nuclear import of proteins by recognizing nuclear localization signals (NLS) in cargo substrates, including histones, RPS3A, TNP2, and VDR. Importin-4 mediates docking to the nuclear pore complex (NPC), allowing translocation through the pore via a Ran-dependent mechanism. It plays a crucial role in the nuclear import of the histone H3-H4 dimer in complex with ASF1 and the ligand-independent nuclear import of vitamin D receptor (VDR).
Therapeutic significance:
Understanding the role of Importin-4 could open doors to potential therapeutic strategies.