Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8WU08
UPID:
ST32A_HUMAN
Alternative names:
Yet another novel kinase 1
Alternative UPACC:
Q8WU08; B3KSY0
Background:
Serine/threonine-protein kinase 32A, also known as Yet another novel kinase 1, plays a crucial role in cellular signaling pathways. This kinase is involved in the phosphorylation of serine and threonine amino acid residues, a key process in the activation and inactivation of enzymes and receptors. Its specific functions and interactions within the cell remain to be fully elucidated, making it a subject of significant scientific interest.
Therapeutic significance:
Understanding the role of Serine/threonine-protein kinase 32A could open doors to potential therapeutic strategies. Its involvement in phosphorylation processes suggests a critical function in cellular regulation and disease mechanisms, highlighting its potential as a target for drug discovery.