Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8WV99
UPID:
ZFN2B_HUMAN
Alternative names:
Arsenite-inducible RNA-associated protein-like protein
Alternative UPACC:
Q8WV99; Q8NB98
Background:
AN1-type zinc finger protein 2B, also known as Arsenite-inducible RNA-associated protein-like protein, plays a crucial role in protein homeostasis. It regulates the translocation and ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum, ensuring the quality control of newly synthesized proteins. This protein is pivotal in managing endoplasmic reticulum stress and indirectly influences the insulin-like growth factor receptor signaling pathway.
Therapeutic significance:
Understanding the role of AN1-type zinc finger protein 2B could open doors to potential therapeutic strategies. Its involvement in protein homeostasis and the insulin-like growth factor receptor signaling pathway suggests its potential as a target in diseases related to protein misfolding and metabolic disorders.