Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8WVB6
UPID:
CTF18_HUMAN
Alternative names:
CHL12
Alternative UPACC:
Q8WVB6; B7ZBA2; D3DU68; Q7Z6Y4; Q7Z6Y6; Q9BR83; Q9BRG5; Q9H7K3
Background:
Chromosome transmission fidelity protein 18 homolog (CHL12) plays a pivotal role in maintaining chromosome cohesion, ensuring accurate sister chromatid cohesion and chromosome transmission. As a component of the CTF18-RFC complex, it is crucial for the ATP-dependent loading of PCNA onto DNA, facilitating DNA replication and repair. This protein's interaction with DNA polymerase POLH and POLE underscores its significance in DNA repair synthesis.
Therapeutic significance:
Understanding the role of Chromosome transmission fidelity protein 18 homolog could open doors to potential therapeutic strategies.