Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8WWA0
UPID:
ITLN1_HUMAN
Alternative names:
Endothelial lectin HL-1; Galactofuranose-binding lectin; Intestinal lactoferrin receptor; Omentin
Alternative UPACC:
Q8WWA0; Q5IWS4; Q5VYI4; Q6YDJ3; Q9NP67
Background:
Intelectin-1, known for its alternative names such as Endothelial lectin HL-1 and Omentin, is a lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. It binds to microbial glycans from both Gram-positive and Gram-negative bacteria, playing a crucial role in the body's defense system against microorganisms. Additionally, it functions as an adipokine enhancing insulin-stimulated glucose uptake in adipocytes and may facilitate iron absorption by interacting with lactoferrin.
Therapeutic significance:
Understanding the role of Intelectin-1 could open doors to potential therapeutic strategies, particularly in enhancing the body's antimicrobial defense mechanisms and improving metabolic health.