Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8WXF1
UPID:
PSPC1_HUMAN
Alternative names:
Paraspeckle protein 1
Alternative UPACC:
Q8WXF1; Q5JTQ3; Q8NCZ9; Q8WXE8; Q9NV36
Background:
Paraspeckle component 1, also known as Paraspeckle protein 1, plays a pivotal role in various cellular processes. It regulates androgen receptor-mediated gene transcription in Sertoli cells, binds to RNA homopolymers, and is crucial for the circadian clock regulation and formation of nuclear paraspeckles. Additionally, it is involved in the DNA virus-mediated innate immune response through the HDP-RNP complex, facilitating IRF3 phosphorylation via the cGAS-STING pathway.
Therapeutic significance:
Understanding the role of Paraspeckle component 1 could open doors to potential therapeutic strategies.