Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8WXI3
UPID:
ASB10_HUMAN
Alternative names:
-
Alternative UPACC:
Q8WXI3; A0AVH0; Q6ZUL6
Background:
Ankyrin repeat and SOCS box protein 10 plays a crucial role in cellular processes as a potential component of a SCF-like ECS E3 ubiquitin-protein ligase complex. This complex is pivotal for the ubiquitination and subsequent proteasomal degradation of target proteins, regulating protein turnover and function.
Therapeutic significance:
Given its involvement in primary open angle glaucoma (POAG), a condition characterized by optic nerve damage and visual field defects, Ankyrin repeat and SOCS box protein 10 presents a promising target for therapeutic intervention. Understanding its role could open doors to novel strategies for managing this asymptomatic yet vision-threatening disease.