Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8WZ75
UPID:
ROBO4_HUMAN
Alternative names:
Magic roundabout
Alternative UPACC:
Q8WZ75; A8K154; Q14DU7; Q8TEG1; Q96JV6; Q9H718; Q9NWJ8
Background:
Roundabout homolog 4, also known as 'Magic roundabout', plays a pivotal role in angiogenesis and vascular patterning. It acts as a receptor for Slit proteins, particularly SLIT2, influencing endothelial cell migration and vascular development. Additionally, it contributes to the maintenance of endothelial barrier organization and function.
Therapeutic significance:
Roundabout homolog 4's involvement in Aortic valve disease 3, characterized by bicuspid aortic valve, aortic valve stenosis, and ascending aortic aneurysm, highlights its potential as a therapeutic target. Understanding the role of Roundabout homolog 4 could open doors to potential therapeutic strategies for cardiovascular diseases.