Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q92540
UPID:
SMG7_HUMAN
Alternative names:
SMG-7 homolog
Alternative UPACC:
Q92540; B4DRB2; E9PCI0; E9PEH2; Q5T1Q0; Q6PIE0; Q7Z7H9; Q8IXC1; Q8IXC2
Background:
Nonsense-mediated mRNA decay factor SMG7, also known as SMG-7 homolog, is pivotal in the nonsense-mediated mRNA decay process. It recruits UPF1 to cytoplasmic mRNA decay bodies, facilitating the degradation of mRNA. SMG7, in conjunction with SMG5, links mRNA decay to exonucleolytic pathways and acts as an adapter for UPF1 to protein phosphatase 2A (PP2A), triggering UPF1 dephosphorylation.
Therapeutic significance:
Understanding the role of Nonsense-mediated mRNA decay factor SMG7 could open doors to potential therapeutic strategies.