Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q92558
UPID:
WASF1_HUMAN
Alternative names:
Protein WAVE-1; Verprolin homology domain-containing protein 1; Wiskott-Aldrich syndrome protein family member 1
Alternative UPACC:
Q92558; E1P5F2; Q5SZK7
Background:
Actin-binding protein WASF1, known as Protein WAVE-1, plays a pivotal role in cellular processes by regulating the actin cytoskeleton. It is a key component of the WAVE complex, influencing lamellipodia formation and actin filament reorganization through interaction with the Arp2/3 complex. Additionally, it is essential for BDNF-NTRK2 endocytic trafficking and signaling, as well as mitochondrial dynamics.
Therapeutic significance:
The involvement of Actin-binding protein WASF1 in neurodevelopmental disorder with absent language and variable seizures highlights its potential as a therapeutic target. Understanding its role could lead to novel strategies for treating this and possibly other neurodevelopmental abnormalities.