Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q92583
UPID:
CCL17_HUMAN
Alternative names:
CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine
Alternative UPACC:
Q92583; A0N0Q9; Q2M287
Background:
C-C motif chemokine 17 (CCL17), also known as TARC, is a pivotal chemokine with a specific role in chemotactic activity for T lymphocytes, especially Th2 cells. It binds to CCR4 on T-cell surfaces, influencing inflammatory and immunological processes. Its involvement extends to GM-CSF/CSF2-driven pain, inflammation, and crucial roles in brain microglia morphology, synaptic plasticity, and wound healing.
Therapeutic significance:
Understanding the role of C-C motif chemokine 17 could open doors to potential therapeutic strategies, particularly in managing inflammatory conditions and enhancing wound healing processes.