Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q92750
UPID:
TAF4B_HUMAN
Alternative names:
Transcription initiation factor TFIID 105 kDa subunit
Alternative UPACC:
Q92750; Q29YA4; Q29YA5
Background:
Transcription initiation factor TFIID subunit 4B, also known as TAF4B, is a pivotal component of the TFIID complex, essential for mediating promoter responses to various activators and repressors. It functions as a cell type-specific subunit, acting as a gene-selective coactivator in certain cells. TAF4B's role extends to the activation of antiapoptotic genes, including TNFAIP3, and it is instrumental in processes such as spermiogenesis and oogenesis.
Therapeutic significance:
TAF4B's involvement in Spermatogenic failure 13, a condition leading to male infertility, underscores its therapeutic potential. Understanding the role of TAF4B could open doors to potential therapeutic strategies for treating infertility issues.