Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q92759
UPID:
TF2H4_HUMAN
Alternative names:
Basic transcription factor 2 52 kDa subunit; General transcription factor IIH polypeptide 4; TFIIH basal transcription factor complex p52 subunit
Alternative UPACC:
Q92759; B4DTJ5; Q76KU4
Background:
General transcription factor IIH subunit 4, also known as the 52 kDa subunit, plays a pivotal role in DNA repair and RNA transcription. It is a core component of the TFIIH complex, essential for nucleotide excision repair (NER) and transcription initiation by RNA polymerase II. This protein facilitates the opening of DNA around lesions for repair and is crucial for promoter opening and escape during transcription initiation.
Therapeutic significance:
Understanding the role of General transcription factor IIH subunit 4 could open doors to potential therapeutic strategies.