Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q92844
UPID:
TANK_HUMAN
Alternative names:
TRAF-interacting protein
Alternative UPACC:
Q92844; D3DPB5; Q7Z4J6; Q92885
Background:
The TRAF family member-associated NF-kappa-B activator, also known as TRAF-interacting protein, plays a pivotal role in regulating immune responses and cell survival mechanisms. It is a key adapter protein that influences I-kappa-B-kinase regulation, antiviral innate immunity, and NF-kappaB signaling pathways. Its ability to interact with various proteins such as TBK1, IKBKE, and TRAF2 underscores its multifunctional nature in cellular processes.
Therapeutic significance:
Understanding the role of TRAF family member-associated NF-kappa-B activator could open doors to potential therapeutic strategies. Its involvement in critical signaling pathways offers a promising avenue for developing interventions aimed at modulating immune responses and enhancing cell survival mechanisms.