Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q92874
UPID:
DNSL2_HUMAN
Alternative names:
DNase I homolog protein DHP1; Deoxyribonuclease I-like 2
Alternative UPACC:
Q92874; E9PBY4; Q6JVM2; Q6JVM3
Background:
Deoxyribonuclease-1-like 2, also known as DNase I homolog protein DHP1 and Deoxyribonuclease I-like 2, plays a crucial role in corneocyte formation of epidermal keratinocytes. It functions as a divalent cation-dependent acid DNA endonuclease, facilitating the breakdown of the nucleus during this process. Additionally, it may have an immune role by eliminating harmful DNA released by damaged epidermal cells into the extracellular environment.
Therapeutic significance:
Understanding the role of Deoxyribonuclease-1-like 2 could open doors to potential therapeutic strategies.