Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q92930
UPID:
RAB8B_HUMAN
Alternative names:
-
Alternative UPACC:
Q92930; Q5JPC4; Q9P293
Background:
Ras-related protein Rab-8B plays a pivotal role in intracellular membrane trafficking, influencing the formation, movement, and fusion of transport vesicles. Its activity is regulated through a cycle between an inactive GDP-bound form and an active GTP-bound form, which recruits various effectors for vesicle dynamics. Rab-8B is particularly implicated in polarized vesicular trafficking and neurotransmitter release, as well as in maintaining cell junction dynamics in Sertoli cells.
Therapeutic significance:
Understanding the role of Ras-related protein Rab-8B could open doors to potential therapeutic strategies.