Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q92949
UPID:
FOXJ1_HUMAN
Alternative names:
Forkhead-related protein FKHL13; Hepatocyte nuclear factor 3 forkhead homolog 4
Alternative UPACC:
Q92949; O00630
Background:
Forkhead box protein J1, also known as Forkhead-related protein FKHL13 and Hepatocyte nuclear factor 3 forkhead homolog 4, is a pivotal transcription factor essential for the formation of motile cilia. It activates genes crucial for assembling motile cilia, targeting DNA sequences to regulate the transcription of various ciliary proteins in the brain and lung.
Therapeutic significance:
Linked to diseases such as Allergic rhinitis and Ciliary dyskinesia, primary, 43, Forkhead box protein J1's role in these conditions underscores its potential as a target for therapeutic intervention. Understanding its function could pave the way for innovative treatments for these respiratory and inflammatory disorders.