Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q92973
UPID:
TNPO1_HUMAN
Alternative names:
Importin beta-2; Karyopherin beta-2; M9 region interaction protein
Alternative UPACC:
Q92973; B4DVC6; Q92957; Q92975
Background:
Transportin-1, also known as Importin beta-2 or Karyopherin beta-2, plays a crucial role in nuclear protein import. It acts as a receptor for nuclear localization signals, facilitating the docking of importin/substrate complexes to the nuclear pore complex. This protein is essential for the nuclear import of M9-containing proteins, ribosomal proteins, and histones, and is involved in the nuclear export of hnRNP A1/A2. Additionally, Transportin-1 mediates the nuclear import of HIV-1 Rev during infection.
Therapeutic significance:
Understanding the role of Transportin-1 could open doors to potential therapeutic strategies.