Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q93091
UPID:
RNAS6_HUMAN
Alternative names:
-
Alternative UPACC:
Q93091
Background:
Ribonuclease K6 is a potent enzyme with a preference for the pyrimidines uridine and cytosine. It exhibits strong antibacterial activity against a wide spectrum of Gram-positive and Gram-negative bacteria, including P. aeruginosa, A. baumanii, and E. coli. This protein disrupts bacterial membrane integrity and promotes the agglutination of Gram-negative bacteria, contributing to urinary tract sterility. Notably, its bactericidal function operates independently of its RNase activity.
Therapeutic significance:
Understanding the role of Ribonuclease K6 could open doors to potential therapeutic strategies. Its broad-spectrum antibacterial efficacy and unique mechanism of action, separate from its enzymatic activity, highlight its potential as a novel antimicrobial agent.