Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It includes extensive molecular simulations of the receptor in its native membrane environment and the ensemble virtual screening accounting for its conformational mobility. In the case of dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets are determined on and between the subunits to cover the whole spectrum of possible mechanisms of action.
Key features that set our library apart include:
partner
Reaxense
upacc
Q969J5
UPID:
I22R2_HUMAN
Alternative names:
Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; Cytokine receptor family type 2, soluble 1; Interleukin-22-binding protein; ZcytoR16
Alternative UPACC:
Q969J5; Q08AH7; Q6UWM1; Q96A41; Q96QR0
Background:
Interleukin-22 receptor subunit alpha-2, known by alternative names such as Cytokine receptor class-II member 10 and Interleukin-22-binding protein, plays a pivotal role in the immune response. Isoform 2 acts as a receptor for IL22, inhibiting its interaction with the IL-22R complex and thereby blocking IL22 activity in vitro. This suggests a crucial function in regulating inflammatory responses. Isoform 1 is implicated in the establishment and maintenance of successful pregnancy, highlighting its significance in reproductive health.
Therapeutic significance:
Understanding the role of Interleukin-22 receptor subunit alpha-2 could open doors to potential therapeutic strategies. Its involvement in modulating inflammatory responses and supporting pregnancy suggests avenues for research in treating inflammatory diseases and fertility issues.