Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q969L4
UPID:
LSM10_HUMAN
Alternative names:
-
Alternative UPACC:
Q969L4
Background:
U7 snRNA-associated Sm-like protein LSm10 plays a pivotal role in the U7 snRNP complex, crucial for histone 3'-end processing. This protein not only enhances U7 snRNA levels when overexpressed but also is essential for the transition from G1 to S phases in the cell cycle. Its unique ability to bind specifically to U7 snRNA and the downstream cleavage product of histone pre-mRNA underscores its significance in cellular processes.
Therapeutic significance:
Understanding the role of U7 snRNA-associated Sm-like protein LSm10 could open doors to potential therapeutic strategies. Its critical function in cell cycle progression and histone processing highlights its potential as a target for therapeutic intervention in diseases where these processes are dysregulated.