Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96A58
UPID:
RERG_HUMAN
Alternative names:
-
Alternative UPACC:
Q96A58; B2R9R0; B4DI02
Background:
The Ras-related and estrogen-regulated growth inhibitor plays a pivotal role in cellular processes by binding GDP/GTP and exhibiting intrinsic GTPase activity. It demonstrates a higher affinity for GDP over GTP, indicating its regulatory function in cellular signaling pathways. Its overexpression in cell lines leads to a notable decrease in proliferation, colony formation, and tumorigenic potential, highlighting its importance in cell growth regulation.
Therapeutic significance:
Understanding the role of Ras-related and estrogen-regulated growth inhibitor could open doors to potential therapeutic strategies. Its ability to modulate cell proliferation and tumorigenic potential makes it a promising target for developing interventions in cancer and other growth-related disorders.