Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96AC1
UPID:
FERM2_HUMAN
Alternative names:
Kindlin-2; Mitogen-inducible gene 2 protein; Pleckstrin homology domain-containing family C member 1
Alternative UPACC:
Q96AC1; B5TJY2; Q14840; Q86TY7
Background:
Fermitin family homolog 2, also known as Kindlin-2, plays a crucial role in cell adhesion, spreading, and the assembly of focal adhesions by interacting with integrins and phospholipid membranes. It is pivotal in linking extracellular matrix adhesion sites with the actin cytoskeleton, orchestrating actin assembly and cell shape modulation. Furthermore, it is involved in the TGFB1 and integrin signaling pathways, stabilizes active CTNNB1, and is essential in Wnt signaling and transcription regulation mediated by CTNNB1 and TCF7L2/TCF4.
Therapeutic significance:
Understanding the role of Fermitin family homolog 2 could open doors to potential therapeutic strategies.