Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96AP4
UPID:
ZUP1_HUMAN
Alternative names:
Lys-63-specific deubiquitinase ZUFSP; Zinc finger with UFM1-specific peptidase domain protein
Alternative UPACC:
Q96AP4; Q5TD92; Q6PJH7; Q96NV6
Background:
Zinc finger-containing ubiquitin peptidase 1 (ZUFSP), also known as Lys-63-specific deubiquitinase, plays a pivotal role in maintaining genome stability by specifically cleaving 'Lys-63'-linked polyubiquitin chains. Its activity is crucial in preventing spontaneous DNA damage and promoting cellular survival under exogenous DNA stress, by modulating the ubiquitination status of replication protein A complex proteins.
Therapeutic significance:
Understanding the role of Zinc finger-containing ubiquitin peptidase 1 could open doors to potential therapeutic strategies.