Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96AZ6
UPID:
ISG20_HUMAN
Alternative names:
Estrogen-regulated transcript 45 protein; Promyelocytic leukemia nuclear body-associated protein ISG20
Alternative UPACC:
Q96AZ6; O00441; O00586
Background:
The Interferon-stimulated gene 20 kDa protein, known alternatively as Estrogen-regulated transcript 45 protein and Promyelocytic leukemia nuclear body-associated protein ISG20, plays a pivotal role in antiviral defense. It acts primarily on single-stranded RNA, showcasing antiviral activity against RNA viruses such as hepatitis C, hepatitis A, and yellow fever virus. Its mechanism involves both the degradation of viral RNAs and the inhibition of viral protein translation, highlighting its critical function in viral genome translation inhibition and ribosome biogenesis.
Therapeutic significance:
Understanding the role of Interferon-stimulated gene 20 kDa protein could open doors to potential therapeutic strategies.