Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96B49
UPID:
TOM6_HUMAN
Alternative names:
Overexpressed breast tumor protein; Translocase of outer membrane 6 kDa subunit homolog
Alternative UPACC:
Q96B49; B2DG15; Q9UH52
Background:
The Mitochondrial import receptor subunit TOM6 homolog, known by its alternative names Overexpressed breast tumor protein and Translocase of outer membrane 6 kDa subunit homolog, plays a crucial role in the mitochondrial import machinery. This protein is essential for the translocation of preproteins across the outer mitochondrial membrane, facilitating their proper localization and function within the mitochondria.
Therapeutic significance:
Understanding the role of Mitochondrial import receptor subunit TOM6 homolog could open doors to potential therapeutic strategies. Its pivotal function in mitochondrial dynamics suggests its involvement in cellular energy metabolism and apoptosis, making it a potential target for therapeutic intervention in diseases where these processes are dysregulated.