Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96BQ3
UPID:
TRI43_HUMAN
Alternative names:
-
Alternative UPACC:
Q96BQ3; Q53TJ7
Background:
Tripartite motif-containing protein 43 (TRIM43) plays a pivotal role in maintaining nuclear lamina integrity and facilitating the interaction between viral and host chromatin. Its unique function as an E3 ligase enables the targeted ubiquitination and subsequent proteasomal degradation of PCNT, a critical process in the cellular defense against herpesvirus infections.
Therapeutic significance:
Understanding the role of Tripartite motif-containing protein 43 could open doors to potential therapeutic strategies. Its specific antiviral mechanism against herpesvirus highlights its potential as a target for developing novel antiviral therapies.