Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96BW1
UPID:
UPP_HUMAN
Alternative names:
-
Alternative UPACC:
Q96BW1; Q5JRL1; Q5JRL3; Q68DN0; Q96MW2
Background:
Uracil phosphoribosyltransferase homolog plays a crucial role in nucleotide metabolism, catalyzing the conversion of uracil and phosphoribosylpyrophosphate to uridine monophosphate and pyrophosphate. This enzymatic activity is fundamental in the salvage pathways of nucleotide synthesis, ensuring the maintenance of a balanced pool of nucleotides for DNA and RNA synthesis.
Therapeutic significance:
Understanding the role of Uracil phosphoribosyltransferase homolog could open doors to potential therapeutic strategies. Its pivotal function in nucleotide metabolism makes it a potential target for the development of drugs aimed at treating metabolic disorders or diseases where nucleotide balance is disrupted.