Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96CM3
UPID:
RUSD4_HUMAN
Alternative names:
RNA pseudouridylate synthase domain-containing protein 4
Alternative UPACC:
Q96CM3; E9PML2; Q96K56
Background:
Pseudouridylate synthase RPUSD4, mitochondrial, also known as RNA pseudouridylate synthase domain-containing protein 4, plays a crucial role in mitochondrial RNA processing. It catalyzes the conversion of uridine to pseudouridine in mitochondrial RNA, impacting the assembly of mitochondrial ribosomes and intra-mitochondrial translation. This enzyme is pivotal for the modification of 16S mitochondrial ribosomal RNA and mitochondrial tRNA(Phe), enhancing the functionality of mitochondrial ribosomes.
Therapeutic significance:
Understanding the role of Pseudouridylate synthase RPUSD4, mitochondrial could open doors to potential therapeutic strategies.