Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q96D96
UPID:
HVCN1_HUMAN
Alternative names:
Hydrogen voltage-gated channel 1; Voltage sensor domain-only protein
Alternative UPACC:
Q96D96; A8MQ37; B4DEB3; F8WCH5; Q6UW11; Q96IS5
Background:
Voltage-gated hydrogen channel 1, also known as Hydrogen voltage-gated channel 1 and Voltage sensor domain-only protein, plays a crucial role in mediating voltage-dependent proton permeability across excitable membranes. This protein forms a proton-selective channel, allowing protons to pass in line with their electrochemical gradient. Its activity is pivotal in facilitating the acute production of reactive oxygen species during phagocytosis, a process essential for the immune response.
Therapeutic significance:
Understanding the role of Voltage-gated hydrogen channel 1 could open doors to potential therapeutic strategies. Its involvement in proton flux and reactive oxygen species production highlights its potential as a target in diseases where these processes are dysregulated.