Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96EM0
UPID:
T3HPD_HUMAN
Alternative names:
Trans-L-3-hydroxyproline dehydratase
Alternative UPACC:
Q96EM0; Q96LJ5
Background:
Trans-3-hydroxy-L-proline dehydratase, also known as Trans-L-3-hydroxyproline dehydratase, plays a crucial role in the metabolism of trans-3-hydroxy-L-proline, a component found in the diet and in the degradation of collagen-IV. This enzyme catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C), a key step in the degradation process.
Therapeutic significance:
Understanding the role of Trans-3-hydroxy-L-proline dehydratase could open doors to potential therapeutic strategies. Its involvement in the metabolism of components from the diet and collagen degradation highlights its importance in physiological processes.