Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q96ES7
UPID:
SGF29_HUMAN
Alternative names:
Coiled-coil domain-containing protein 101; SAGA complex-associated factor 29
Alternative UPACC:
Q96ES7; Q96MF5
Background:
SAGA-associated factor 29, also known as Coiled-coil domain-containing protein 101, plays a pivotal role in chromatin modification and gene expression. It is a chromatin reader in SAGA-type complexes, recognizing and binding methylated 'Lys-4' of histone H3, with a preference for the trimethylated form. This protein is essential for recruiting the SAGA complex to H3K4me, facilitating histone H3 acetylation and cell survival, especially under endoplasmic reticulum stress.
Therapeutic significance:
Understanding the role of SAGA-associated factor 29 could open doors to potential therapeutic strategies.