Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q96EV8
UPID:
DTBP1_HUMAN
Alternative names:
Biogenesis of lysosome-related organelles complex 1 subunit 8; Dysbindin-1; Dystrobrevin-binding protein 1; Hermansky-Pudlak syndrome 7 protein
Alternative UPACC:
Q96EV8; A8K3V3; Q5THY3; Q5THY4; Q96NV2; Q9H0U2; Q9H3J5
Background:
Dysbindin, also known as Biogenesis of lysosome-related organelles complex 1 subunit 8, plays a crucial role in the biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. It is involved in synaptic vesicle trafficking, neurotransmitter release, and may modulate MAPK8 phosphorylation and actin cytoskeleton reorganization.
Therapeutic significance:
Dysbindin's association with Hermansky-Pudlak syndrome 7, a disorder characterized by oculocutaneous albinism, bleeding, and lysosomal storage defects, highlights its potential as a target for therapeutic intervention. Understanding the role of Dysbindin could open doors to potential therapeutic strategies.