Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96GC5
UPID:
RM48_HUMAN
Alternative names:
39S ribosomal protein L48, mitochondrial
Alternative UPACC:
Q96GC5; B4DN34; Q49AK7; Q4U2Q4; Q9P091; Q9Y5J0
Background:
The Large ribosomal subunit protein mL48, also known as 39S ribosomal protein L48, mitochondrial, plays a crucial role in the synthesis of proteins within the mitochondria. Its involvement in the mitochondrial ribosome suggests a fundamental contribution to mitochondrial protein translation, essential for cellular energy production and metabolic processes.
Therapeutic significance:
Understanding the role of Large ribosomal subunit protein mL48 could open doors to potential therapeutic strategies. Its pivotal function in protein synthesis within mitochondria highlights its importance in cellular metabolism and energy production, making it a potential target for therapeutic intervention in diseases related to mitochondrial dysfunction.